Keratinocyte Growth Factor Stimulates Migration and Hyaluronan Synthesis in the Epidermis by Activation of Keratinocyte Hyaluronan Synthases 2 and 3

Hyaluronan accumulation in wounded epidermis: a mediator of keratinocyte activation.

The high-molecular-mass polysaccharide hyaluronan is abundant in the extracellular space between adjacent keratinocytes throughout the vital part of epidermis. It has a rapid turnover, and its content is subject to large fluctuations due to physiological and environmental conditions, with the strongest effects mediated by EGFR signaling. Using an elegant organotypic culture system, Monslow et a...

Hyaluronan Synthases from Streptococcus versus Pasteurella bacteria Hyaluronan Synthesis by Class I Hyaluronan Synthases Functional Sizes of the Hyaluronan Synthases Purification and Characterization of the Streptococcal Hyaluronan Synthases The Phospholipid Requirement of the Streptococcal Hyaluronan Synthases

Expression of hyaluronan synthases and hyaluronan in malignant mesothelioma cells.

BACKGROUND Hyaluronan is one of the main components of the extracellular matrix. It is synthesized at the cell plasma membrane by specific hyaluronan synthases (HAS). Although a large number of studies have described hyaluronan in pleural effusion from malignant mesothelioma, the source of hyaluronan in malignant mesothelioma has been subject to controversy. MATERIALS AND METHODS The mRNA exp...

Hyaluronan and hyaluronan synthases: potential therapeutic targets in cancer.

Current models of oncogenesis describe cancer as a progression of genetic mutations in a tumor cell mass. However, tumors are more than a clonal expansion of malignant cells. Tumors are heterogeneous, with a complex 3D structure, analogous to organs comprised of different tissues. In a tumor mass, the component cell types interact with each other and with their microenvironment by exchanging in...

Keratinocyte growth factor-2 stimulates P-glycoprotein expression and function in intestinal epithelial cells.

Intestinal P-glycoprotein (Pgp/multidrug resistance 1), encoded by the ATP-binding cassette B1 gene, is primarily involved in the transepithelial efflux of toxic metabolites and xenobiotics from the mucosa into the gut lumen. Reduced Pgp function and expression has been shown to be associated with intestinal inflammatory disorders. Keratinocyte growth factor-2 (KGF2) has emerged as a potential ...